Why the study?
Does the addition of hydralazine to propranolol increase plasma volume and extracellular fluid volume in patients with uncontrolled hypertension?
Population
16 patients with hypertension not satisfactorily controlled by propranolol alone (mean dosage 325 mg/day)
Comparison
Addition of hydralazine for three months vs Baseline (before addition of hydralazine)
Design
Cohort
Follow-up
3 months
Authors
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Hydralazine added to propranolol was associated with volume expansion; supports diuretic co-therapy consideration but leaves open need for randomized trials.
Does the addition of hydralazine to propranolol increase plasma volume and extracellular fluid volume in patients with uncontrolled hypertension?
The addition of hydralazine to propranolol in hypertensive patients causes significant fluid retention, suggesting the need for concomitant diuretic therapy.
Ibsen et al. (1978) studied this question.
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