Key result
Histological and molecular analysis of the left ventricular aneurysm wall revealed destruction of cardiomyocyte basement membranes and decreased expression of extracellular matrix genes in the hypokinesis zone compared to the normokinesis zone.
Why the study?
Hibernating myocardium with the potential for functional recovery is of clinical and scientific interest.
Case Report (n=1)
No
Hibernating myocardium in left ventricular aneurysms exhibits structural destruction and altered extracellular matrix gene expression, suggesting it may not be capable of restoring contractile function.
Answers are grounded in this paper and cite their sources.
Single-case molecular analysis of hibernating myocardium is hypothesis-generating; leaves open clinical relevance and generalizability.
No abstract yet. The journal hasn't published one we can show.
No takes yet. Share an insight, caveat, or question.
Popov et al. (2024) conducted a case report in Ischemic heart disease, left ventricular aneurysm (n=1). Hypokinesis zone of the left ventricular aneurysm wall vs. Normokinesis zone was evaluated on Histological structure and differential gene expression of extracellular matrix proteins. Histological and molecular analysis of the left ventricular aneurysm wall revealed destruction of cardiomyocyte basement membranes and decreased expression of extracellular matrix genes in the hypokinesis zone compared to the normokinesis zone.
Synapse has enriched 10 related papers. Consider them for comparative context: