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July 1, 1964Applied MicrobiologyOpen Access

Production and Purification of Milligram Amounts of Foot-and-Mouth Disease Virus From Baby Hamster Kidney Cell Cultures

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Population

Baby hamster kidney cell cultures

Design

Preclinical

Follow-up

6 to 7 days

Authors

JPJerome PolatnickPlum Island Animal Disease CenterHBHoward L. BachrachAgricultural Research Service

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Implication

Enables scalable FMDV antigen production in BHK cultures; leaves open translation to veterinary vaccines pending in vivo trials.

Structured PICO

P
Population
Baby hamster kidney cell cultures
I
Intervention
Growth in a tris(hydroxymethyl)aminomethane buffer-containing medium on cylindrical surfaces of 2-liter Baxter bottles rotated on a three-tiered roller mill
O
Outcome
Yield of foot-and-mouth disease virus (FMDV) and mass of purified virussurrogate

The described method allows for the large-scale production and purification of milligram amounts of foot-and-mouth disease virus using baby hamster kidney cell cultures.

Cite This Study

Polatnick et al. (1964) studied this question.

synapsesocial.com/papers/6a7cd8080eb18aa3c85aebb1https://doi.org/10.1128/am.12.4.368-373.1964
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Submerged Culture of Mammalian Cells: The Spinner Culture,1957 · 362 citations
  2. 2The Measurement of Proliferation in Tissue Cultures by Enumeration of Cell Nuclei1951 · 348 citations