Population
Xenopus oocytes expressing BK channels containing four sequence variants in four different isoforms of the…
Comparison
Expression of the beta3b-V4 variant vs Wild-type beta3b channels
Design
Preclinical
Authors
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May implicate BK channel variants in epilepsy; hypothesis-generating and should not yet inform clinical practice.
The beta3b-V4 variant of the KCNMB3 regulatory subunit alters BK channel inactivation, potentially reducing neuronal inhibition and contributing to idiopathic epilepsy.
Hu et al. (2003) studied this question.
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