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February 4, 2020Angiology

Higher MPV (OR = 2.13, 95% CI: 1.57-2.90, P < .0001), NLR (OR = 1.23, 95% CI: 1.11-1.37, P < .0001), PLR (OR = 1.13, 95% CI: 1.07-1.20, P < .0001), and hsCRP (OR = 1.03, 95% CI: 1.01-1.05, P = .006) were significantly associated with higher no-reflow incidence.

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Why the study?

CRP, hsCRP, and hematological indices including PLR, NLR, MPV, PDW, and RDW are regarded to be related to the incidence of no-reflow or slow flow following coronary intervention.

Do higher inflammatory and hematological indices predict no-reflow or slow flow in patients undergoing coronary intervention?

Population

7403 patients across 21 studies

Comparison

Higher vs lower inflammatory and hematological indices

Design

Systematic review and meta-analysis

Authors

EZEnyuan ZhangMGMingdong GaoJGJing Gao

Discussion

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Member takes

Overview

May aid pre-PCI risk stratification with routine labs; leaves open prospective validation and outcome impact.

Structured PICO

Do higher inflammatory and hematological indices predict no-reflow or slow flow in patients undergoing coronary intervention?

P
Population
7,403 patients undergoing coronary intervention pooled from 21 clinical studies
I
Intervention
Higher preangiographic levels of inflammatory and hematological indices (CRP, hsCRP, NLR, PLR, MPV, PDW, RDW)
C
Comparator
Lower preangiographic levels of inflammatory and hematological indices
O
Outcome
Incidence of no-reflow or slow flowsurrogate

Preangiographic inflammatory and hematological indices, particularly MPV, NLR, PLR, and hsCRP, can serve as simple predictors for the risk of no-reflow and slow flow following coronary intervention.

Cite This Study

Zhang et al. (2020) studied this question.

synapsesocial.com/papers/6a7e4cdb1fdb7ee677c76b27https://doi.org/10.1177/0003319719896472
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Meta-analysis of the correlation between inflammatory response indices and no-reflow after PCI in patients with acute STEMI2024 · 9 citations
  2. 2Predictive accuracy of lymphocyte-to-monocyte ratio and monocyte-to-high-density-lipoprotein-cholesterol ratio in determining the slow flow/no-reflow phenomenon in patients with non–ST-elevated myocardial infarction2020 · 37 citations
  3. 3Clinical and Laboratory Predictors of No-reflow during Primary Percutaneous Coronary Intervention2021 · 1 citations
  4. 4The combination of neutrophil-to-lymphocyte ratio and platelet correlation parameters in predicting the no-reflow phenomenon after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction2020 · 17 citations
  5. 5The Utility the Platelet-to-Lymphocyte Ratio in Predicting Angiographic Reflow after Primary Percutaneous Coronary Intervention in Patients with Acute ST- Segment Elevation Myocardial Infarction2018