June 1, 2003Journal of Cardiovascular Pharmacology and Therapeutics

The Combination of Nebivolol plus Pravastatin is Associated with a More Beneficial Metabolic Profile Compared to that of Atenolol plus Pravastatin in Hypertensive Patients with Dyslipidemia: A Pilot Study

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Why the study?

Does nebivolol compared to atenolol improve the metabolic profile in hypertensive patients with dyslipidemia?

Structured PICO

Does nebivolol compared to atenolol improve the metabolic profile in hypertensive patients with dyslipidemia?

Population

30 hypertensive hyperlipidemic men and women (total cholesterol >240 mg/dL, low-density lipoprotein cholesterol >190 mg/dL, triglycerides <500 mg/dL)

Intervention

Nebivolol 5 mg daily for 12 weeks, followed by the addition of pravastatin 40 mg daily for another 12 weeks

Comparator

Atenolol 50 mg daily for 12 weeks, followed by the addition of pravastatin 40 mg daily for another 12 weeks

Outcome

Metabolic profile (including lipids, fibrinogen, high-sensitivity C-reactive protein, homocysteine, uric acid, glucose, insulin, and HOMA index)surrogate

Nebivolol demonstrates a more favorable metabolic profile compared to atenolol in hypertensive patients with dyslipidemia, particularly regarding insulin resistance and triglyceride levels.

Discussion

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Implication

Nebivolol was associated with favorable triglyceride and HOMA changes versus atenolol; leaves open need for randomized outcome trials before practice consideration.

Cite This Study

Rizos et al. (2003) studied this question.

synapsesocial.com/papers/6a7ea0b21cd7fb25e38b9816 https://doi.org/10.1177/107424840300800206

Topics

Hypertension management

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Implication

Nebivolol was associated with favorable triglyceride and HOMA changes versus atenolol; leaves open need for randomized outcome trials before practice consideration.

The Combination of Nebivolol plus Pravastatin is Associated with a More Beneficial Metabolic Profile Compared to that of Atenolol plus Pravastatin in Hypertensive Patients with Dyslipidemia: A Pilot Study

Structured PICO

Discussion

Implication

Cite This Study

Topics

The Combination of Nebivolol plus Pravastatin is Associated with a More Beneficial Metabolic Profile Compared to that of Atenolol plus Pravastatin in Hypertensive Patients with Dyslipidemia: A Pilot Study

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider