Population
Stably transformed cell lines derived from African green monkey kidney and fetal rhesus monkey kidney cells…
Comparison
Transfection with plasmid DNAs containing… vs Transcripts containing the 5'NTR of wild-type…
Design
Preclinical
Authors
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Cell-type-specific HAV translation enhancement warrants caution in generalization; leaves open in vivo and clinical relevance.
Mutations in the 5'NTR of a cell culture-adapted hepatitis A virus enhance viral replication by facilitating cap-independent translation in a cell-type-specific fashion.
Schultz et al. (1996) studied this question.
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