November 1, 1998Journal of VirologyOpen Access

Heterogeneous Nuclear Ribonucleoprotein L Interacts with the 3′ Border of the Internal Ribosomal Entry Site of Hepatitis C Virus

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Structured PICO

Population

Hepatitis C virus (HCV) RNA and cellular proteins

Intervention

Binding of heterogeneous nuclear ribonucleoprotein L (hnRNP L) to the HCV internal ribosomal entry site (IRES)

Outcome

Interaction of cellular proteins with the 3' border of the HCV IRES and correlation with translational efficiencysurrogate

Identifies hnRNP L as a cellular protein that binds to the HCV IRES and may play an important role in HCV mRNA translation.

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hnRNP L may modulate HCV translation; leaves open its viability as an antiviral target pending validation.

Hahm et al. (1998) studied this question.

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