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May 1, 1994Journal of Hypertension

BQ-123, a selective endothelin subtype A-receptor antagonist, lowers blood pressure in different rat models of hypertension

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Why the study?

Does BQ-123 reduce blood pressure in rat models of hypertension?

Population

Conscious, unrestrained spontaneously hypertensive rats, normotensive Wistar-Kyoto rats and renin…

Design

Preclinical

Follow-up

up to 14 h after cessation of infusion

Authors

SDStephen A. DouglasUniversity of MinnesotaMGMiklos GellaiDartmouth CollegeMEMildred EzekielUnited States Department of Veterans Affairs

Discussion

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Implication

Endothelin A antagonism merits further hypertension research; animal data leave clinical translation unresolved.

Structured PICO

Does BQ-123 reduce blood pressure in rat models of hypertension?

P
Population
Conscious, unrestrained spontaneously hypertensive rats (SHR), normotensive Wistar-Kyoto (WKY) rats and renin hypertensive rats
I
Intervention
Sustained infusions of BQ-123 (0.16-164 nmol/kg per min, intravenously, for 6 h)
O
Outcome
Mean arterial pressuresurrogate

The selective endothelin subtype A-receptor antagonist BQ-123 lowers blood pressure in hypertensive rat models, highlighting the role of endothelin in hypertension.

Cite This Study

Douglas et al. (1994) studied this question.

synapsesocial.com/papers/6a815e8fadfa6baaaee1cf5fhttps://doi.org/10.1097/00004872-199405000-00009

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of BQ-123, an Endothelin Antagonist, on Renal Hemodynamics, Tubular Function, Vasoactive Hormones, and Blood Pressure in Healthy Humans: A Dose Response Study2005 · 9 citations
  2. 2EFFECTS OF A SELECTIVE ENDOTHELIN A‐RECEPTOR ANTAGONIST, BQ‐123, IN SALT‐LOADED STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS1995 · 25 citations
  3. 3Blood Pressure–Independent Reduction in Proteinuria and Arterial Stiffness After Acute Endothelin-A Receptor Antagonism in Chronic Kidney Disease2009 · 130 citations
  4. 4BQ123, an ETA Receptor Antagonist, Attenuates Endothelin-1-Induced Vasoconstriction in Rat Pulmonary Circulation1993 · 57 citations
  5. 5Action of the endothelin receptor (ETA) antagonist BQ-123 on forearm blood flow in young normotensive subjects2002 · 4 citations