Why the study?
Do centrally acting antihypertensive agents clonidine and flesinoxan reduce blood pressure variability in spontaneously hypertensive rats?
Population
Conscious spontaneously hypertensive rats (SHRs)
Design
Preclinical
Follow-up
4 weeks
Authors
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These preclinical findings warrant no clinical practice change; extends mechanistic insights into sympathetic modulation of BP variability.
Do centrally acting antihypertensive agents clonidine and flesinoxan reduce blood pressure variability in spontaneously hypertensive rats?
Centrally mediated inhibition of sympathetic tone by clonidine or flesinoxan reduces blood pressure variability independently of modifications in overall blood pressure levels in hypertensive rats.
Chaouche‐Teyara et al. (1997) studied this question.
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