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January 1, 1993Journal of Hypertension

Vascular smooth muscle responses to endothelial autacoids in rats with chronic coarctation hypertension

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Why the study?

Does elevated intravascular pressure in chronic hypertension alter responses of vascular smooth muscle to agents of endothelial origin in rats?

Population

Coarctation hypertensive, sham normotensive control, and one-kidney, one clip hypertensive (1K1C) rats

Comparison

Histamine, endothelin-1, iloprost, and… vs Sham normotensive control rats

Design

Preclinical

Authors

DBDavid BellScotland's Rural College

Discussion

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Implication

Chronic pressure exposure may impair endothelial relaxation in hypertensive rat models; leaves open translation to human vessels or therapies.

Structured PICO

Does elevated intravascular pressure in chronic hypertension alter responses of vascular smooth muscle to agents of endothelial origin in rats?

P
Population
Coarctation hypertensive, sham normotensive control, and one-kidney, one clip hypertensive (1K1C) rats
I
Intervention
Histamine, endothelin-1, iloprost, and nitroglycerin applied to isolated helically cut strips of thoracic and abdominal aortas
C
Comparator
Sham normotensive control rats
O
Outcome
Vascular smooth muscle relaxation responsessurrogate

Chronic exposure to elevated arterial pressure impairs endothelium-dependent vasorelaxation by histamine in hypertensive rat models.

Cite This Study

David Bell (1993) studied this question.

synapsesocial.com/papers/6a829f8863f679ce4646f10ehttps://doi.org/10.1097/00004872-199301000-00010

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelium in functional aortic changes of coarctation hypertension1991 · 23 citations
  2. 2The Influence of Coarctation Hypertension on the Pharmacodynamic Behaviour of Rat Isolated Conduit Vessels1994 · 8 citations
  3. 3Increased resistance and impaired maximal vasodilation in normotensive vascular beds of rats with coarctation hypertension.1979 · 31 citations
  4. 4Increased arteriolar wall-to-lumen ratio in a normotensive vascular bed in coarctation hypertension1985 · 18 citations
  5. 5Alteration of endothelial function in arterioles of renal hypertensive rats at two levels of vascular tone1992 · 17 citations