Population
Isolated vertebral arteries from hypertensive and normotensive human subjects obtained 18-24 h post mortem
Comparison
Exposure to serotonin (10M) and endothelin (10M) vs Arteries from normotensive subjects
Design
Preclinical
Authors
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Hypertensive arteries show higher oscillatory activity; leaves open mechanistic relevance and human translation in this animal model.
Vertebral arteries from hypertensive subjects exhibit abnormal oscillatory contractile activity in response to agonists, likely related to altered calcium entry into smooth muscle cells.
Webb et al. (1992) studied this question.
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