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July 1, 1994AJP Heart and Circulatory Physiology

Effects of high-dose intracoronary irradiation on vasomotor function and smooth muscle histopathology

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Why the study?

Does high-dose intracoronary gamma-irradiation alter vasomotor function and histopathology in porcine coronary arteries?

Population

Porcine coronary arteries

Design

Preclinical

Follow-up

32 days

Authors

JWJ WiedermannNewYork–Presbyterian HospitalJLJeffrey A. LeavyNewYork–Presbyterian HospitalHAHoward AmolsMemorial Sloan Kettering Cancer Center

Discussion

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Implication

Suggests differential vasomotor recovery after irradiation in porcine arteries; hypothesis-generating for restenosis prevention without human data.

Structured PICO

Does high-dose intracoronary gamma-irradiation alter vasomotor function and histopathology in porcine coronary arteries?

P
Population
Porcine coronary arteries
I
Intervention
High-dose intracoronary gamma-irradiation
O
Outcome
Vasomotor function acutely and at 32 days, and smooth muscle histopathology at 32 dayssurrogate

High-dose intracoronary gamma-irradiation in a porcine model induces focal medial fibrosis without significant endothelial or myocardial damage, highlighting its potential to prevent restenosis.

Cite This Study

Wiedermann et al. (1994) studied this question.

synapsesocial.com/papers/6a82c5efd88fdfcf4fa0cbbchttps://doi.org/10.1152/ajpheart.1994.267.1.h125
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intracoronary irradiation markedly reduces restenosis after balloon angioplasty in a porcine model1994 · 314 citations
  2. 2Intracoronary Irradiation with 186/188Rhenium Following Balloon Overstretch Injury Reduces Neointima But Does Not Impair Vasoreactivity of Porcine Coronary Arteries1999 · 4 citations
  3. 3Intracoronary irradiation for the prevention of restenosis1997 · 18 citations
  4. 4Intracoronary irradiation for the prevention of restenosis1997 · 15 citations
  5. 5Effect of Intravascular Irradiation on Cell Proliferation, Apoptosis, and Vascular Remodeling After Balloon Overstretch Injury of Porcine Coronary Arteries1997 · 169 citations