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January 1, 1963Scandinavian Journal of Clinical and Laboratory Investigation

Quantitative Determination of Quinidine in Plasma

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Authors

GCGun CramérSahlgrenska University HospitalBIB IsakssonLund University

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Implication

Methodological study demonstrates a quantitative assay for measuring quinidine in human plasma, suggesting improved precision for therapeutic drug monitoring.

Key Points

  • To establish and evaluate an analytical laboratory procedure for the precise quantitative measurement of quinidine concentrations in blood plasma.
  • Outlined an extraction and analytical protocol tailored to isolate quinidine from plasma specimens for clinical laboratory analysis.
  • Standardized assay conditions to enable reproducible measurement of drug concentrations across physiological ranges.
  • Demonstrated an effective analytical method capable of quantifying plasma quinidine concentrations to support clinical pharmacology evaluations.
  • Provided a standardized measurement framework designed to minimize assay interference and assist in preventing toxic drug accumulation.

Cite This Study

Cramér et al. (1963) studied this question.

synapsesocial.com/papers/6a83080f1557c09efd7d5956https://doi.org/10.1080/00365516309079786
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1STUDIES ON THE ACTION OF QUINIDINE IN MAN1943 · 29 citations
  2. 2QUINIDINE IN THE TREATMENT OF AURICULAR FIBRILLATION IN ASSOCIATION WITH CONGESTIVE FAILURE1946 · 32 citations
  3. 3CHRONIC AURICULAR FIBRILLATION1947 · 17 citations
  4. 4Blood Quinidine Concentrations as a Guide in the Treatment of Cardiac Arrhythmias1950 · 109 citations
  5. 5Factors Influencing Conversion of Chronic Atrial Fibrillation with Special Reference to Serum Quinidine Concentration1956 · 112 citations