February 1, 1989Journal of Hypertension
Kidney renin mRNA levels in the early and chronic phases of two-kidney, one clip hypertension in the rat
Why the study?
Does clipping the left renal artery alter kidney renin mRNA levels in the early and chronic phases of two-kidney, one clip hypertension in rats?
Population
Rat model of two-kidney, one clip Goldblatt hypertension
Comparison
Clipping the left renal artery vs Sham-operated control rats
Design
Preclinical
Follow-up
Up to 20 weeks
Authors
Discussion
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Member takes
Implication
Offers mechanistic insight into experimental renovascular hypertension; leaves open translation to clinical practice.
Structured PICO
Does clipping the left renal artery alter kidney renin mRNA levels in the early and chronic phases of two-kidney, one clip hypertension in rats?
P
Population
Rat model of two-kidney, one clip Goldblatt hypertension
I
Intervention
Clipping the left renal artery
C
Comparator
Sham-operated control rats
O
Outcome
Renin mRNA levels in the left and right kidneyssurrogate
In a rat model of two-kidney, one clip hypertension, renin gene expression is profoundly and persistently altered, with upregulation in the clipped kidney and suppression in the contralateral kidney.
Cite This Study
Samani et al. (1989) studied this question.