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November 1, 1993American Journal of Hypertension

Renin, Angiotensinogen, and Kallikrein Gene Expression in Two-Kidney Goldblatt Hypertensive Rats

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Population

Rats (two-kidney Goldblatt hypertensive model)

Comparison

Placement of a 0.25-mm clip on the left renal… vs Sham-operated rats

Design

Preclinical

Follow-up

25 days

Authors

SESamir S. El‐DahrTulane UniversitySDSusana DippOchsner Medical CenterSGShangbo GuanTulane University

Discussion

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Implication

Supports potential pathogenetic role of renin-kallikrein dysregulation in experimental renovascular hypertension; leaves open relevance to human disease.

Structured PICO

P
Population
Rats (two-kidney Goldblatt hypertensive model)
I
Intervention
Placement of a 0.25-mm clip on the left renal artery
C
Comparator
Sham-operated rats
O
Outcome
Expression of renin, angiotensinogen (Ao), and tissue kallikrein genessurrogate

The differential regulation of renin-angiotensin and kallikrein genes may be an important pathogenetic factor in renovascular hypertension.

Cite This Study

El‐Dahr et al. (1993) studied this question.

synapsesocial.com/papers/6a8d16cae32d502f9909a037https://doi.org/10.1093/ajh/6.11.914
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Modulation of renin-angiotensin and kallikrein gene expression in experimental hypertension.1994 · 42 citations
  2. 2Expression of Angiotensin-Converting Enzyme in Renovascular Hypertensive Rat Kidney1995 · 30 citations
  3. 3Kidney renin mRNA levels in the early and chronic phases of two-kidney, one clip hypertension in the rat1989 · 49 citations
  4. 4Role of tissue renin angiotensin system in two-kidney, one-clip hypertensive rats1993 · 24 citations
  5. 5Sequential activation of the intrarenal renin-angiotensin system in the progression of hypertensive nephropathy in Goldblatt rats2016 · 25 citations