November 30, 2005Clinical Journal of the American Society of Nephrology
Lessons Learned from Recent Hypertension Trials about Kidney Disease
Why the study?
Does antihypertensive therapy targeting blood pressure and proteinuria reduction improve cardiovascular and renal outcomes in patients with chronic kidney disease?
Population
Patients with chronic kidney disease and hypertension
Design
Review
Authors
Discussion
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Member takes
Implication
Supports dual BP-proteinuria targeting in CKD; leaves open optimal thresholds and agent effects pending RCTs.
Structured PICO
Does antihypertensive therapy targeting blood pressure and proteinuria reduction improve cardiovascular and renal outcomes in patients with chronic kidney disease?
P
Population
Patients with chronic kidney disease and hypertension
I
Intervention
Antihypertensive therapy targeting blood pressure and proteinuria reduction
O
Outcome
Cardiovascular events and kidney disease progression
Baseline proteinuria and the magnitude of its reduction are critical determinants of renal outcomes beyond blood pressure lowering alone.
Limitations
- Comparing trials of people with different stages of nephropathy and unknown or differing levels of proteinuria limits generalizability
Cite This Study
Khosla et al. (2005) studied this question.