Long-term outcome in relation to renal sympathetic activity in patients with chronic heart failure
Why the study?
Does elevated renal noradrenaline spillover predict all-cause mortality and heart transplantation in patients with chronic heart failure?
Population
61 patients with chronic heart failure, NYHA I-IV, and left ventricular ejection fraction 26+/-9%
Comparison
Renal noradrenaline spillover above median vs Renal noradrenaline (NA) spillover below median
Design
Cohort
Follow-up
median 5.5 years (range 12 days to 11.6 years)
Authors
Discussion
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Member takes
Implication
May aid prognostication in chronic HF; hypothesis-generating for renal sympathetic targeting and requires prospective validation.
Structured PICO
Does elevated renal noradrenaline spillover predict all-cause mortality and heart transplantation in patients with chronic heart failure?
P
Population
61 patients with chronic heart failure, NYHA I-IV (66% NYHA III-IV), and left ventricular ejection fraction (LVEF) 26+/-9%
I
Intervention
Renal noradrenaline (NA) spillover above median (1.19 nmol/min)
C
Comparator
Renal noradrenaline (NA) spillover below median
O
Outcome
Combined endpoint of all-cause mortality and heart transplantationcomposite
Renal noradrenergic activation is a strong independent predictor of mortality and heart transplantation in patients with chronic heart failure.
Cite This Study
Petersson et al. (2005) studied this question.