Sex-Specific Associations of Cardiovascular Risk Factors and Biomarkers With Incident Heart Failure
Key result
Cardiovascular risk factors were strongly associated with incident heart failure in both sexes (p<0.001), yielding good discrimination in men (C-statistic 0.80) and women (C-statistic 0.83).
Why the study?
It was unclear whether cardiovascular disease risk factors and biomarkers associate differentially with heart failure risk in men and women.
Do cardiovascular risk factors and biomarkers associate differentially with incident heart failure risk in men and women?
Population
22,756 participants free of HF at baseline from 4 community-based cohorts
Comparison
Sex-specific associations of CV risk factors and biomarkers with incident HF
Design
Pooled cohort study across 4 community-based cohorts
Follow-up
12.5 years
Authors
Discussion
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Member takes
Overview
Supports uniform HF risk prediction with standard factors across sexes; extends observational data but leaves open biomarker refinement.
Study Design
Type
Cohort (n=22,756)
Multicenter
Yes
Structured PICO
Do cardiovascular risk factors and biomarkers associate differentially with incident heart failure risk in men and women?
P
Population
22,756 community-dwelling adults (mean age 60, 53% women) free of heart failure at baseline, followed for 12.5 years.
E
Exposure
Evaluation of cardiovascular risk factors and biomarkers (natriuretic peptides, cardiac troponins, plasminogen activator inhibitor-1, D-dimer, fibrinogen, C-reactive protein, sST2, galectin-3, cystatin-C, and urinary albumin-to-creatinine ratio)
O
Outcome
Incident heart failurehard clinical
Main Result
p-value: p=<0.001
Cardiovascular risk factors are strongly and similarly associated with incident heart failure in both men and women, with biomarkers adding only limited predictive value to clinical models.
Cite This Study
Suthahar et al. (2020) conducted a cohort in Incident Heart Failure (n=22,756). Cardiovascular risk factors and biomarkers was evaluated on Incident heart failure (p=<0.001). Cardiovascular risk factors were strongly associated with incident heart failure in both sexes (p<0.001), yielding good discrimination in men (C-statistic 0.80) and women (C-statistic 0.83).