July 1, 1995Annals of the New York Academy of Sciences

Effect of I₁‐Imidazoline Receptor Activation on Responses of Hypoglossal and Phrenic Nerve to Chemical Stimulationfn1

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Population

Cats (preclinical model)

Comparison

Moxonidine, clonidine, SK&F-86466, and efaroxan vs Control

Design

Preclinical

Authors

MHMusa A. HaxhiuCleveland Clinic IDIsmail A DreshajBrigham and Women's Hospital BEBernadette O. ErokwuCase Western Reserve University

Discussion

Member takes

Implication

Moxonidine may preserve chemosensitivity during BP reduction in animals; leaves open translation to human respiratory safety versus clonidine.

Structured PICO

Population

Cats (preclinical model)

Intervention

Moxonidine (3-100 micrograms/kg i.v.), clonidine, SK&F-86466 (0.5 or 1 mg/kg), and efaroxan

Comparator

Control

Outcome

Responses of phrenic, hypoglossal, and cervical sympathetic nerve activities to progressive hypercapnia after hyperventilation to apneasurrogate

Selective I1-imidazoline receptor activation with moxonidine lowers blood pressure without depressing central respiratory chemosensitivity, unlike the mixed I1/alpha-2 agonist clonidine.

Cite This Study

Haxhiu et al. (1995) studied this question.

synapsesocial.com/papers/6a851fdeacfb9ccf0c928af6 https://doi.org/10.1111/j.1749-6632.1995.tb32435.x

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Implication

Moxonidine may preserve chemosensitivity during BP reduction in animals; leaves open translation to human respiratory safety versus clonidine.

Effect of I₁‐Imidazoline Receptor Activation on Responses of Hypoglossal and Phrenic Nerve to Chemical Stimulationfn1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of I₁‐Imidazoline Receptor Activation on Responses of Hypoglossal and Phrenic Nerve to Chemical Stimulationfn1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider