Why the study?
Does periaxonal application of capsaicin selectively ablate afferent renal nerves and attenuate hypertension in rats?
Population
Rats (preclinical model for renal denervation and hypertension)
Comparison
Periaxonal application of capsaicin to renal… vs Control
Design
Preclinical
Follow-up
7 weeks
Authors
Loading...
Offers validated method for selective afferent ablation in rats; leaves open clinical translation for salt-sensitive hypertension.
Does periaxonal application of capsaicin selectively ablate afferent renal nerves and attenuate hypertension in rats?
Periaxonal application of capsaicin provides a validated preclinical method for selective ablation of afferent renal nerves, demonstrating their role in the development of salt-induced hypertension.
Foss et al. (2014) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: