Key result
Carvedilol plus N-acetyl cysteine reduced postoperative total oxidative stress compared with metoprolol (19.3 vs 29.6; P<0.0001) and carvedilol alone (19.3 vs 24.2; P<0.0001).
Why the study?
Does carvedilol plus N-acetyl cysteine reduce oxidative stress, inflammation, and postoperative atrial fibrillation compared to metoprolol or carvedilol alone in surgical patients?
Observational
Does carvedilol plus N-acetyl cysteine reduce oxidative stress, inflammation, and postoperative atrial fibrillation compared to metoprolol or carvedilol alone in surgical patients?
Absolute Event Rate: 19.3% vs 29.6%
p-value: p=<0.0001
Carvedilol combined with N-acetyl cysteine significantly reduces postoperative oxidative stress and inflammation compared to metoprolol or carvedilol alone, which are associated with postoperative atrial fibrillation.
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Carvedilol plus N-acetyl cysteine was associated with lower postoperative oxidative stress; hypothesis-generating for POAF prevention and requires randomized confirmation.
Özaydın et al. (2014) conducted an observational in Postoperative atrial fibrillation. Carvedilol plus N-acetyl cysteine (NAC) vs. Metoprolol or carvedilol alone was evaluated on Postoperative total oxidative stress (TOS) (p=<0.0001). Carvedilol plus N-acetyl cysteine reduced postoperative total oxidative stress compared with metoprolol (19.3 vs 29.6; P<0.0001) and carvedilol alone (19.3 vs 24.2; P<0.0001).
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