Why the study?
Does ETA/ETB receptor blockade or ECE inhibition alter the clearance mechanisms and sites of ET-1 and BigET-1 in Wistar-Kyoto rats?
Does ETA/ETB receptor blockade or ECE inhibition alter the clearance mechanisms and sites of ET-1 and BigET-1 in Wistar-Kyoto rats?
ET-1 and BigET-1 have distinct clearance mechanisms, with ET-1 cleared rapidly via pulmonary ETB receptors and BigET-1 cleared slower via non-receptor mechanisms in the liver and kidneys.
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Rat study delineates ET-1 versus Big-ET-1 clearance pathways; leaves open translation to human endothelin disorders or therapies.
Burkhardt et al. (2000) studied this question.
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