Why the study?
Does the plasma level of oral propranolol reliably predict the degree of β-blockade in chronically treated patients?
Population
28 patients chronically treated with oral propranolol
Design
Cross-sectional
Authors
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Plasma propranolol levels should not yet guide β-blockade assessment in chronic therapy; leaves open pharmacodynamic variability as a research target.
Does the plasma level of oral propranolol reliably predict the degree of β-blockade in chronically treated patients?
The degree of β-blockade cannot be reliably estimated from propranolol plasma levels alone due to dichotomous concentration-effect ratios among patients.
Zacest et al. (2008) studied this question.
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