Key result
Peak plasma propranolol was linearly related to dose over the range 160 to 960 mg/day (correlation coefficient = 0.96), with unexpectedly small between-patient variation.
Why the study?
Does chronic propranolol therapy produce predictable plasma levels in hospitalized patients with hypertension or coronary artery disease?
Population
n=46 hospitalized patients with hypertension or coronary artery disease
Design
Cohort
Authors
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May support predictable dosing in hospitalized hypertension or CAD patients; extends PK observations but leaves open prospective validation.
Observational (n=46)
Does chronic propranolol therapy produce predictable plasma levels in hospitalized patients with hypertension or coronary artery disease?
Effect estimate: correlation coefficient = 0.96
The oral dose of propranolol predicts a narrow plasma concentration range, indicating uniform pharmacokinetics that could aid in dose selection and compliance evaluation.
Walle et al. (1978) conducted an observational in hypertension or coronary artery disease (n=46). Propranolol was evaluated on Relationship between peak plasma propranolol and dose over the range 160 to 960 mg (correlation coefficient = 0.96). Peak plasma propranolol was linearly related to dose over the range 160 to 960 mg/day (correlation coefficient = 0.96), with unexpectedly small between-patient variation.
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