Why the study?
Do modified commercial assay kits improve the sensitivity and early detection of hepatitis A antibodies following vaccination?
Population
Serum samples for detecting antibody to hepatitis A virus (anti-HAV), particularly following vaccination
Comparison
Modified Abbott HAVAB-M assay and modified… vs Standard (unmodified) commercial assay kits
Design
Other
Authors
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May enable earlier vaccine response monitoring clinically; leaves open standardization and outcome impact pending prospective validation.
Do modified commercial assay kits improve the sensitivity and early detection of hepatitis A antibodies following vaccination?
Modifying commercial hepatitis A antibody assays increases sensitivity 5- to 20-fold, allowing earlier detection post-vaccination.
Miller et al. (1993) studied this question.
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