Why the study?
Does continuous intravenous infusion of synthetic bradykinin alter hemodynamic parameters in patients undergoing heart catheterization?
Does continuous intravenous infusion of synthetic bradykinin alter hemodynamic parameters in patients undergoing heart catheterization?
Intravenous infusion of synthetic bradykinin induces significant systemic and pulmonary vasodilation with a compensatory increase in cardiac output and heart rate.
Bradykinin infusion should not change practice; hypothesis-generating for vasodilator effects in cardiovascular disease.
The general hemodynamic effects induced by a continuous intravenous infusion of synthetic bradykinin were studied in ten patients submitted to simultaneous right- and left-heart catheterization. A significant drop in systemic arterial pressure and in total peripheral resistance was observed, coincident with an increase of the cardiac output, heart rate, and stroke volume. There was no consistent change of the pulmonary arterial and left atrial pressures, but the pulmonary vascular resistance decreased significantly.
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FREITAS et al. (1964) studied this question.
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