August 1, 1981AJP Heart and Circulatory Physiology

Production of chronic heart block in closed-chest dogs: an improved technique

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Population

38 closed-chest anesthetized dogs

Design

Preclinical

Authors

OROtelio S. RandallUniversity of Southern California NWNicolaas WesterhofBrooke Army Medical Center GBG. C. van den BosCharing Cross Hospital

Discussion

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Implication

May enable efficient closed-chest canine models of chronic heart block; leaves open translation to clinical electrophysiology.

Structured PICO

Population

38 closed-chest anesthetized dogs

Intervention

Injection of a Formalin mixture (0.2-1.0 ml, consisting of equal amounts of 40% Formalin and radiopaque material) into the His bundle via a special cannula introduced via a jugular vein

Outcome

Production of chronic complete heart block

A technique involving the injection of a Formalin mixture into the His bundle successfully produced chronic complete heart block in 90% of closed-chest dogs.

Cite This Study

Randall et al. (1981) studied this question.

synapsesocial.com/papers/6a87e7b63f31f6b699bb6c2f https://doi.org/10.1152/ajpheart.1981.241.2.h279

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Production of chronic heart block in closed-chest dogs: an improved technique

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Production of chronic heart block in closed-chest dogs: an improved technique

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider