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September 26, 2016Clinical and Experimental Hypertension

Ankle-brachial index and brachial-ankle pulse wave velocity are associated with albuminuria in community-based Han Chinese

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Key result

Ankle-brachial index (OR 0.89; 95% CI 0.81-0.99 per 0.1 unit increase) and highest quartile of brachial-ankle pulse wave velocity (OR 1.18; 95% CI 1.04-1.47) were associated with albuminuria.

Why the study?

Are ankle-brachial index and brachial-ankle pulse wave velocity associated with albuminuria in elderly community-based Han Chinese?

Population

2127 community-based Han Chinese subjects (860 men, 1267 women) aged 60 years and over in Beijing.

Design

Cross-sectional

Authors

XXXi-Qi XuMinistry of Education of the People's Republic of ChinaJHJinggui HeSWShuxia Wang

Discussion

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Implication

May support ABI/baPWV for albuminuria risk stratification in elderly Chinese; hypothesis-generating and requires prospective validation.

Study Design

Type

Observational (n=2,127)

Structured PICO

Are ankle-brachial index and brachial-ankle pulse wave velocity associated with albuminuria in elderly community-based Han Chinese?

P
Population
2,127 community-based Han Chinese adults aged 60 years and older recruited in Beijing to assess the association of arterial stiffness markers with albuminuria.
E
Exposure
Ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) assessment
O
Outcome
Albuminuria (urinary albumin-to-creatinine ratio ≥30 mg/g)surrogate

Main Result

Odds Ratio: 0.89 (95% CI 0.81–0.99)

Lower ABI and higher baPWV are associated with an increased risk of albuminuria in elderly Chinese individuals, particularly those with hypertension and diabetes.

Cite This Study

Xu et al. (2016) conducted an observational in Albuminuria (n=2,127). Ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) vs. Lower quartiles (for baPWV) was evaluated on Albuminuria (urinary albumin-to-creatinine ratio ≥30 mg/g) (OR 0.89, 95% CI 0.81-0.99). Ankle-brachial index (OR 0.89; 95% CI 0.81-0.99 per 0.1 unit increase) and highest quartile of brachial-ankle pulse wave velocity (OR 1.18; 95% CI 1.04-1.47) were associated with albuminuria.

synapsesocial.com/papers/6a88167da95381ace1bbf9b7https://doi.org/10.1080/10641963.2016.1182177

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Higher brachial-ankle pulse wave velocity as an independent risk factor for future microalbuminuria in patients with essential hypertension: the J-TOPP study2009 · 51 citations
  2. 2Comparison of Ankle-Brachial Index and Brachial-Ankle Pulse Wave Velocity between Patients with Chronic Kidney Disease and Hemodialysis2008 · 17 citations
  3. 3Association of low ankle-brachial index with mortality in patients with ischemic heart disease2010 · 15 citations
  4. 4Effects of Glucose Metabolism on Aortic Pulse Wave Velocity in Hemodialysis Patients with and without Diabetes2008 · 15 citations
  5. 5Elevated Brachial-Ankle Pulse Wave Velocity Is Independently Associated with Microalbuminuria in a Rural Population2014 · 11 citations