Why the study?
Does the A allele of the rs2285666 SNP in the ACE2 gene reduce the risk of fatal cardiovascular events in females?
Population
5,092 participants of the prospective MORGAM study from five cohorts
Comparison
A allele of the rs2285666 single nucleotide… vs Subset of MORGAM participants selected to ensure…
Design
Cohort
Authors
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Supports further investigation of ACE2 variants in women; does not yet inform clinical risk assessment.
Does the A allele of the rs2285666 SNP in the ACE2 gene reduce the risk of fatal cardiovascular events in females?
The A allele of the rs2285666 SNP in the ACE2 gene is associated with a significantly lower risk of fatal cardiovascular events in females, suggesting a plausible biological role for ACE2 in cardiovascular disease risk.
Vangjeli et al. (2011) studied this question.
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