Why the study?
Can first-pass nuclear angiocardiography accurately detect left-to-right cardiac shunts in horses?
Can first-pass nuclear angiocardiography accurately detect left-to-right cardiac shunts in horses?
First-pass nuclear angiocardiography, particularly using the QP:QS method, effectively detects left-to-right ventricular septal defects in horses.
May aid equine shunt detection; leaves open clinical validation and translation to practice.
First‐pass nuclear angiocardiography was performed on 13 normal horses and 5 horses with confirmed left‐to‐right ventricular septal defects. Two methods of analyzing the ensuing pulmonary time‐activity histograms for shunt recirculation through the lungs were evaluated: (1) pulmonary‐to‐systemic blood flow ratio (QP:QS), based on gamma variate modeling of the lung histogram, and (2) a simple count‐ratio method (C2:C1). Normal values were QP:QS=1.17±0.04 and C2:C1=0.40±0.07. Values for the five horses with left‐to‐right shunts were QP:QS=2.94±0.13 and C2:C1=0.76±0.11. Both parameters showed significant differences (unpaired t ‐test; p <0.005) between the two groups, although separation was better with QP:QS.
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Koblik et al. (1987) studied this question.
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