Key result
Radionuclide angiocardiography accurately quantifies left-to-right shunts, discriminating Qp/Qs ratios above or below 1.2.
Why the study?
A new method for determining pulmonary-to-systemic flow ratios (Qp/Qs) in patients with left-to-right shunts was needed to improve accuracy and quantitation over existing methods.
Observational (n=35)
May enable simple noninvasive Qp/Qs quantitation; leaves open prospective validation in larger cohorts before clinical use.
A new method of determining pulmonary-to-systemic flow ratios (Qp/Qs) in patients with left-to-right shunts using radionuclide angiocardiography is described. It involves the analysis of pulmonary time-activity histograms using a gamma-variate model. It appears to be simple, relatively atraumatic, and superior to the methods using C 2 /C 1 ratios because, in addition to accurately detecting the presence of left-to-right shunts, it permits precise quantitation. In the 35 patients studied, it was found that Qp/Qs <1.2 could be separated from Qp/Qs > 1.2 and that when the Qp/Qs is between 1.2 and <3 the shunts could be accurately quantified.
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Maltz et al. (1973) conducted an observational in Left-to-right shunts (n=35). Radionuclide angiocardiography using a gamma-variate model vs. Methods using C2/C1 ratios was evaluated on Determination and quantitation of pulmonary-to-systemic flow ratios (Qp/Qs). Radionuclide angiocardiography using a gamma-variate model accurately detected and quantified left-to-right shunts, separating Qp/Qs <1.2 from >1.2.
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