Why the study?
Does C4d deposition identify myocardial infarction after ischemia-reperfusion injury in a rat cardiac transplantation model?
Population
16 Fischer 344 rats weighing 200-270 g undergoing isogenic heterotopic cardiac transplantation to induce…
Comparison
Ligation of the left anterior descending… vs Ischemia-reperfusion injury alone without LAD…
Design
Preclinical, The rats were randomized into 2 groups., Evaluation of histology…
Follow-up
2 days
Authors
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C4d may mark early MI in rat IRI grafts; hypothesis-generating for biomarker translation to human cardiac transplantation.
Does C4d deposition identify myocardial infarction after ischemia-reperfusion injury in a rat cardiac transplantation model?
Increased C4d deposition may serve as a novel biomarker to identify early myocardial infarction after cardiac arrest and ischemia-reperfusion injury.
Vuohelainen et al. (2015) studied this question.
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