Why the study?
Does voriconazole cause QT interval prolongation and ventricular tachycardia in a patient with acute lymphoblastic leukemia and Fusarium infection?
Does voriconazole cause QT interval prolongation and ventricular tachycardia in a patient with acute lymphoblastic leukemia and Fusarium infection?
Voriconazole can cause non-concentration-dependent QT interval prolongation and ventricular tachycardia, mandating cardiac rhythm monitoring during treatment.
Voriconazole may induce QT prolongation and NSVT independent of levels; case report leaves open need for monitoring in leukemia patients.
A 15-year-old patient with acute lymphoblastic leukemia and Fusarium infection was treated with voriconazole. She developed asymptomatic bradycardia, QT interval prolongation, and nonsustained, polymorphic ventricular tachycardia, which recurred upon rechallenge with the drug. Voriconazole levels and metabolism were within expected normal values. This non-concentration-dependent, voriconazole-associated ventricular tachycardia mandates cardiac rhythm monitoring during voriconazole treatment.
No takes yet. Share an insight, caveat, or question.
Alkan et al. (2004) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: