The low permissiveness of monkey cells to EMC virus is likely due to more than one restrictive event affecting RNA synthesis.
Suggests multiple host restrictions limit EMC virus replication in primate cells; leaves open the specific mechanisms for targeted virology research.
Encephalomyocarditis (EMC) virus replicates to high titre in permissive mouse kidney (MKS) cells but poorly in monkey kidney (CV1) cells. The permissiveness of monkey-mouse hybrid cells varies according to their chromosomal content. In monkey cells, the synthesis of both single-stranded and double-stranded virus RNA is restricted; in semi-permissive hybrid clones, the double-stranded RNA is synthesized normally, whereas the synthesis of the single-stranded RNA is inhibited. Thus, it seems that more than one restrictive event is responsible for the low permissiveness of monkey cells to EMC virus.
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Dubois et al. (1976) studied this question.
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