July 1, 1982The Journal of Cell Biology

Evidence that myosin does not contribute to force production in chromosome movement.

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Why the study?

Does microinjected antimyosin inhibit chromosome movement in actively dividing cells?

Population

Actively dividing cells

Comparison

Microinjected antibody against cytoplasmic myosin vs Buffer alone, myosin-absorbed antibody, or…

Design

Preclinical

Authors

DKDaniel P. KiehartMarine Biological Laboratory IMIssei MabuchiOtsuma Women's University SISaki InouéThe University of Osaka

Discussion

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Implication

Antimyosin distinguishes cytokinesis from anaphase mechanics; leaves open myosin-independent mitotic forces in mammalian cells.

Structured PICO

Does microinjected antimyosin inhibit chromosome movement in actively dividing cells?

Population

Actively dividing cells

Intervention

Microinjected antibody against cytoplasmic myosin (anti-Asterias egg myosin)

Comparator

Buffer alone, myosin-absorbed antibody, or nonimmune gamma-globulin

Outcome

Rate or extent of anaphase chromosome movements, central spindle elongation, and chromosomal fiber shorteningsurrogate

This study provides direct physiological evidence that myosin is responsible for force production in cytokinesis but is not involved in force production for chromosome movement.

Cite This Study

Kiehart et al. (1982) studied this question.

synapsesocial.com/papers/6a89b7ecd89205768aeb44ff https://doi.org/10.1083/jcb.94.1.165

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Ask AI

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Evidence that myosin does not contribute to force production in chromosome movement.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evidence that myosin does not contribute to force production in chromosome movement.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider