Why the study?
Does alpha-human atrial natriuretic peptide affect renin release in vitro and in vivo?
Population
Rat renal cortical slices and human subjects including normotensive subjects, patients with essential…
Comparison
alpha-human atrial natriuretic peptide 10 to 10… vs Basal state / no alpha-hANP
Design
Other
Authors
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ANP lacks direct effect on renin release; leaves open indirect RAAS modulation for further in vivo study.
Does alpha-human atrial natriuretic peptide affect renin release in vitro and in vivo?
Atrial natriuretic peptide does not appear to directly affect renin release from the juxtaglomerular apparatus in vitro or in vivo.
Ishimitsu et al. (1992) studied this question.
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