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November 8, 2025Current Heart Failure ReportsOpen Access

Multicomponent, multiprofessional interventions consistently improve outcomes such as reducing hospitalizations, enhancing function, and lowering mortality risk, though current evidence is heterogeneous.

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Why the study?

Frailty affects up to 45% of adults with HF and worsens health care utilization and survival through shared pathophysiologic mechanisms, necessitating effective multidisciplinary management strategies.

Do multicomponent or interdisciplinary interventions improve outcomes in adults with heart failure and frailty?

Design

Comprehensive review

Authors

IUIzabella UchmanowiczMJMaria JędrzejczykLHLoreena Hill

Discussion

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Member takes

Overview

Integrating frailty assessment into HF care may refine risk stratification and management; leaves open optimal intervention strategies.

Key Points

  • Synthesize current evidence on the pathophysiologic overlap between frailty and heart failure and assess the impact of multidisciplinary, multicomponent interventions on patient outcomes.
  • Narrative synthesis of recent clinical trials evaluating interventions targeting frailty in adults with heart failure.
  • Evaluation of multiprofessional care strategies incorporating exercise training, nutritional support, medication optimization, psychological care, and caregiver education.
  • Frailty affects up to 45% of adults with heart failure, driven by shared pathways of chronic inflammation, neurohormonal abnormalities, and multiorgan dysfunction.
  • Multicomponent regimens integrating resistance and balance training with individualized nutrition reduce hospital readmissions and improve physical performance.
  • Multidisciplinary care teams—including cardiologists, nurses, therapists, and dieticians—slow frailty progression and enhance health-related quality of life.

Structured PICO

Do multicomponent or interdisciplinary interventions improve outcomes in adults with heart failure and frailty?

P
Population
Adults with heart failure and frailty
I
Intervention
Multicomponent or interdisciplinary interventions addressing two or more care domains (e.g., physiotherapy, occupational therapy, nutrition, psychology, social work, nursing)

Managing frailty in patients with heart failure requires a personalized, holistic, and multicomponent approach integrating physical, nutritional, and psychosocial interventions to improve clinical outcomes and reduce healthcare utilization.

Limitations

  • Search limited to English-language publications, which may have introduced language bias
  • Heterogeneity in frailty definitions, assessment tools and intervention components precluded formal meta-analysis
  • Many included studies had small sample sizes or short-term follow-up

Cite This Study

Uchmanowicz et al. (2025) studied this question.

synapsesocial.com/papers/6a89d1e536a409ff8cf7bf31https://doi.org/10.1007/s11897-025-00727-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Patient and Clinician Perspectives on a Multicomponent Frailty Intervention for Adults With Heart Failure: A Qualitative Study2026
  2. 2Frailty and heart failure: State‐of‐the‐art review2023 · 141 citations
  3. 3Frailty and Heart Failure: An Integrated Review of a Bidirectional Relationship2026
  4. 4Multidimensional and Multidisciplinary Management of Heart Failure Patients with Frailty2026
  5. 5Mapping interventions addressing frailty and associated outcomes in people with heart failure: a scoping review2026