Why the study?
Do the SA and Na+/K+-ATPase alpha1 genes co-segregate with elevated blood pressure in the Milan hypertensive rat?
Population
F2 rats from a cross of Milan hypertensive and Milan normotensive rats, and 6 and 25 weeks old Milan…
Comparison
Genotyping of SA and Na+/K+-ATPase alpha1 genes… vs Milan normotensive rats
Design
Preclinical
Authors
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Preclinical data rule out these genes as hypertension drivers in Milan rats; leaves open other loci for genetic hypertension research.
Do the SA and Na+/K+-ATPase alpha1 genes co-segregate with elevated blood pressure in the Milan hypertensive rat?
The SA and Na+/K+-ATPase alpha1 genes do not appear to be the primary genetic determinants of elevated blood pressure in the Milan hypertensive rat model.
Lodwick et al. (1998) studied this question.
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