Key result
CMR-derived global circumferential strain emerged as the strongest predictor of myocardial infarction size >25% in STEMI patients with preserved LVEF, demonstrating an AUC of 0.836.
Why the study?
The correlation between myocardial strain and myocardial infarction size by cardiac magnetic resonance imaging in STEMI patients with preserved LVEF is not clear.
Does CMR-derived global circumferential strain accurately predict myocardial infarction size in STEMI patients with preserved LVEF?
Population
31 STEMI patients after primary PCI with preserved LVEF and 21 healthy adults
Comparison
STEMI patients with preserved LVEF vs healthy controls
Design
Retrospective study
Authors
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May aid identification of larger infarcts in preserved-LVEF STEMI; hypothesis-generating pending prospective validation.
Observational (n=52)
No
Does CMR-derived global circumferential strain accurately predict myocardial infarction size in STEMI patients with preserved LVEF?
Effect estimate: AUC 0.836 (95% CI 0.692-0.981)
Absolute Event Rate: 0.836% vs 0.673%
p-value: p=0.001
In STEMI patients with preserved LVEF, CMR-derived global circumferential strain is a superior surrogate marker for predicting myocardial infarct size compared to LVEF.
Wang et al. (2022) conducted an observational in ST-segment elevation myocardial infarction with preserved left ventricular ejection fraction (n=52). Global circumferential strain (GCS) by CMR vs. Left ventricular ejection fraction (LVEF) was evaluated on Diagnostic accuracy (AUC) for predicting late gadolinium enhancement (LGE) size >25% (AUC 0.836, 95% CI 0.692-0.981, p=0.001). CMR-derived global circumferential strain emerged as the strongest predictor of myocardial infarction size >25% in STEMI patients with preserved LVEF, demonstrating an AUC of 0.836.
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