Key result
A mammalian K+ channel in immortalized human kidney epithelial cells was directly inhibited by cGMP in a concentration-dependent manner, with a 34% reduction in open probability at 0.1 mM.
Population
Immortalized human kidney epithelial cells (IHKE-1)
Comparison
Application of K+ channel blockers and regulators vs Baseline/control conditions
Design
Preclinical
Authors
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Preclinical data preclude clinical application; leaves open cGMP regulation of renal K+ channels in vivo.
This study provides the first electrophysiological characterization of a mammalian K+ channel that is directly regulated by cGMP in human kidney epithelial cells.
Hirsch et al. (1999) studied Immortalized human kidney epithelial cells (IHKE-1). cGMP was evaluated on Open probability (Po) of the K+ channel. A mammalian K+ channel in immortalized human kidney epithelial cells was directly inhibited by cGMP in a concentration-dependent manner, with a 34% reduction in open probability at 0.1 mM.
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