Why the study?
Does once-daily metoprolol control blood pressure and improve compliance in patients with mild to moderate hypertension?
Does once-daily metoprolol control blood pressure and improve compliance in patients with mild to moderate hypertension?
Once-daily metoprolol can control mild to moderate hypertension in a general practice setting, though side effects are more common in older patients.
May support once-daily metoprolol for BP control in general practice hypertension; leaves open compliance and age-related tolerability questions.
The results of an uncontrolled and open study of a once-a-day dosage of metoprolol (Betaloc) in the management of mild to moderate hypertension are described. The study was conducted by a group general practice. The trial was designed to test if metoprolol taken only once a day, could improve patient compliance. This would also result in less expense to the patient. Of the 161 patients who started the trial, 144 patients remained in it. Hypertension was fully controlled in 84 patients, but 33 failed to respond to metoprolol therapy. Because of side effects, 27 abandoned the trial. The remaining 17 patients withdrew from the drug trial for reasons unrelated to metoprolol. The efficacy of metoprolol was not influenced by a person's sex, but the number of side effects was significantly increased in older patients.
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R. Malcolm Fredman (1982) studied this question.
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