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December 2, 1976New England Journal of Medicine

Reciprocal Relation between Renin Dependency and Sodium Dependency in Essential Hypertension

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Why the study?

Does sodium balance determine the blood-pressure response to saralasin in patients with essential hypertension?

Population

14 patients with essential high-renin, normal-renin, and low-renin hypertension

Design

Other

Authors

HGHaralambos GavrasGeneral / Preventive / LipidsARArtur Beltrame RibeiroHospital do Rim e HipertensãoHBHans R. BrunnerGeneral / Preventive / Lipids

Discussion

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Implication

Sodium balance dictates RAS contribution to BP across all renin subgroups; leaves open applicability to modern RAS inhibitors.

Structured PICO

Does sodium balance determine the blood-pressure response to saralasin in patients with essential hypertension?

P
Population
14 patients with essential high-renin, normal-renin, and low-renin hypertension
I
Intervention
Saralasin (competitive antagonist of angiotensin II) administered during periods of sodium depletion and repletion
O
Outcome
Blood-pressure response to saralasinsurrogate

Sodium balance determines the degree of participation of the renin-angiotensin system in sustaining high blood pressure across all renin subgroups of essential hypertension.

Cite This Study

Gavras et al. (1976) studied this question.

synapsesocial.com/papers/6a8bab91dbcda37421e94beehttps://doi.org/10.1056/nejm197612022952302

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plasma Renin Activity and Aldosterone Secretion in Hypertensive Patients During High and Low Sodium Intake and Administration of Diuretic11968 · 98 citations
  2. 2Hypertension of Renal Origin: Evidence for Two Different Mechanisms1971 · 336 citations
  3. 3The renin system: Variations in man measured by radioimmunoassay or bioassay1972 · 383 citations
  4. 4Artery Wall Electrolytes in Renal and Dca hypertension11954 · 147 citations
  5. 5Use of an Angiotensin II Antagonist (Saralasin) in the Recognition of “Angiotensinogenic” Hypertension1975 · 277 citations