January 1, 1980The Journal of Infectious Diseases

The Role of Host Genetics in the Pathogenesis of Coxsackievirus Infection in the Pancreas of Mice

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Population

Three strains of mice susceptible to the diabetogenic effect of the M variant of encephalomyocarditis virus…

Comparison

Infection with human coxsackie virus, group B… vs Comparison between MEMC-susceptible…

Design

Preclinical

Authors

SWS.R. WebbVirginia Commonwealth University GMGordon E. MadgeVirginia Commonwealth University

Discussion

Member takes

Implication

May implicate shared genetic susceptibility to viral beta-cell effects in diabetes-prone models; leaves open human translation.

Structured PICO

Population

Three strains of mice susceptible to the diabetogenic effect of the M variant of encephalomyocarditis (MEMC) virus, three strains not susceptible to MEMC virus, and three types of F1 hybrid strains

Intervention

Infection with human coxsackie virus, group B, type 4 (CB4)

Comparator

Comparison between MEMC-susceptible, MEMC-nonsusceptible, and F1 hybrid strains

Outcome

Titer of virus and histochemistry in the pancreas, levels of blood glucose, urinalysis, glucose tolerance, and levels of plasma amylase and insulinsurrogate

Genetic factors responsible for the effect of MEMC virus on the endocrine pancreas in mice are also responsive to CB4, maintaining a recessive nature for both viruses.

Cite This Study

Webb et al. (1980) studied this question.

synapsesocial.com/papers/6a8bd3a8effeb02058b1ec4f https://doi.org/10.1093/infdis/141.1.47

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The Role of Host Genetics in the Pathogenesis of Coxsackievirus Infection in the Pancreas of Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Role of Host Genetics in the Pathogenesis of Coxsackievirus Infection in the Pancreas of Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider