January 1, 1988Intervirology

Attachment, Uncoating and Blockage of Cell Protein Synthesis by Sabin Derivatives of Poliovirus in HeLa and Vero Cells

View Full Paper

Ask AI

Bookmark

Population

HeLa and Vero cells

Comparison

Infection with virulent Mah type 1 poliovirus… vs Comparison between HeLa and Vero cells

Design

Preclinical

Authors

DTDaniel R. TershakPennsylvania State University RMRaminder MakkarPennsylvania State University

Discussion

Member takes

Implication

Caution advised when extrapolating poliovirus behavior from Vero cell models; leaves open mechanisms of attenuation for further validation.

Structured PICO

Population

HeLa and Vero cells

Intervention

Infection with virulent Mah type 1 poliovirus and attenuated Sab types 1, 2, and 3 poliovirus

Comparator

Comparison between HeLa and Vero cells

Outcome

Viral attachment, eclipse, and blockage of cellular protein synthesissurrogate

The restricted growth of poliovirus in Vero cells compared to HeLa cells is likely due to lower rates of attachment, eclipse, and limited capacity to block cellular protein synthesis.

Cite This Study

Tershak et al. (1988) studied this question.

synapsesocial.com/papers/6a8bdd43f71b672e3df49f56 https://doi.org/10.1159/000150058

View Full Paper

Ask AI

Bookmark

Implication

Caution advised when extrapolating poliovirus behavior from Vero cell models; leaves open mechanisms of attenuation for further validation.

Attachment, Uncoating and Blockage of Cell Protein Synthesis by Sabin Derivatives of Poliovirus in HeLa and Vero Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Attachment, Uncoating and Blockage of Cell Protein Synthesis by Sabin Derivatives of Poliovirus in HeLa and Vero Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider