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March 1, 1999HypertensionOpen Access

Human Renin mRNA Stability Is Increased in Response to cAMP in Calu-6 Cells

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Population

Human carcinoma-derived cell line Calu-6

Comparison

Forskolin or phorbol ester treatment vs Unstimulated cells

Design

Preclinical

Authors

PSPatrick L. SinnUniversity of IowaCSCurt D. SigmundVascular Medicine

Discussion

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Implication

Posttranscriptional renin mRNA stabilization may regulate expression; leaves open in vivo relevance to hypertension.

Structured PICO

P
Population
Human carcinoma-derived cell line Calu-6
I
Intervention
Forskolin or phorbol ester treatment
C
Comparator
Unstimulated cells
O
Outcome
hREN mRNA stability and half-lifesurrogate

Induction of human renin mRNA by cAMP and phorbol ester in Calu-6 cells is mediated by posttranscriptional stabilization.

Cite This Study

Sinn et al. (1999) studied this question.

synapsesocial.com/papers/6a8c17af510c7253b5dede53https://doi.org/10.1161/01.hyp.33.3.900
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cyclic AMP selectively increases renin mRNA stability in cultured juxtaglomerular granular cells.1993 · 102 citations
  2. 2The Kidney Androgen-regulated Protein Promoter Confers Renal Proximal Tubule Cell-specific and Highly Androgen-responsive Expression on the Human Angiotensinogen Gene in Transgenic Mice1997 · 160 citations
  3. 3Transcriptional induction of the human renin gene by cyclic AMP requires cyclic AMP response element-binding protein (CREB) and a factor binding a pituitary-specific trans-acting factor (Pit-1) motif1996 · 53 citations
  4. 4Renin gene promoter activity in GC cells is regulated by cAMP and thyroid hormone through Pit-1-dependent mechanisms.1994 · 35 citations
  5. 55,6-Dichloro-1-β-D-ribofuranosylbenzimidazole inhibits transcription elongation by RNA polymerase II in vitro1989 · 239 citations