March 1, 1996American Journal of Hypertension

Central depressor action of nitric oxide is deficient in genetic hypertension

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Population

Genetically hypertensive rats (SHRSP) and normotensive rats (WKY)

Comparison

Intracerebroventricular administration of nitric… vs Normotensive rats (WKY)

Design

Preclinical

Authors

CCCamilo CabreraUniversity of Concepción

Discussion

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Implication

Central NOS deficit in hypertensive rat models warrants no clinical action; leaves open its role in human hypertension.

Structured PICO

Population

Genetically hypertensive rats (SHRSP) and normotensive rats (WKY)

Intervention

Intracerebroventricular (ICV) administration of nitric oxide (NO), calcium (to stimulate NOS), N omega-nitro-L-arginine methyl ester (L-NAME, to block NOS), or cGMP blockade; electrolytic ablation of the anteroventral third cerebral ventricle (AV3V)

Comparator

Normotensive rats (WKY)

Outcome

Change in mean arterial pressure (MAP)surrogate

A deficit in central nitric oxide synthase activity may contribute to elevated arterial pressure in genetically hypertensive rats.

Cite This Study

Camilo Cabrera (1996) studied this question.

synapsesocial.com/papers/6a8c18aa3c68152a7ce97eff https://doi.org/10.1016/0895-7061(95)00292-8

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Central depressor action of nitric oxide is deficient in genetic hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Central depressor action of nitric oxide is deficient in genetic hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider