Key result
Transmural nerve stimulation elicited a frequency-dependent, tetrodotoxin-resistant relaxation in isolated canine saphenous veins (maximum relaxation 3.4 +/- 0.21 g) that was abolished by ouabain.
Population
Isolated canine saphenous vein rings
Comparison
Transmural nerve stimulation applied as… vs Various pharmacological inhibitors and physical…
Design
Preclinical
Authors
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Hypothesis-generating for TTX-resistant venous relaxation in canines; leaves open mechanism and human relevance without further study.
The study demonstrates a nonadrenergic noncholinergic relaxation to TNS in the canine saphenous vein that is resistant to tetrodotoxin, suggesting mediation by a TTX-resistant nerve or direct smooth muscle effect.
Senaratne et al. (1984) studied this question. Transmural nerve stimulation (TNS) was evaluated on Relaxation response. Transmural nerve stimulation elicited a frequency-dependent, tetrodotoxin-resistant relaxation in isolated canine saphenous veins (maximum relaxation 3.4 +/- 0.21 g) that was abolished by ouabain.
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