February 16, 2025Veterinary ResearchOpen Access

BEV 2C protein inhibits the NF-κB signalling pathway to promote viral replication by targeting IKBKB and p65

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Why the study?

The mechanisms by which bovine enteroviruses evade the host immune response and promote their replication remain unclear.

Population

HY12 strain of enterovirus model

Design

Preclinical laboratory study

Authors

XCXuyuan CuiJilin University YGYidi GuoNanjing University of Chinese Medicine FZFan ZhangWuhan College

Discussion

Member takes

Implication

BEV 2C inhibition of NF-κB may aid viral persistence in cattle; leaves open targeted antiviral development pending in vivo validation.

Structured PICO

Population

Bovine enterovirus HY12 strain model (host interaction)

Intervention

BEV 2C protein (specifically N-terminal 1-121 aa)

Outcome

Viral replication and NF-κB pathway inhibition (down-regulation of IKBKB, interaction with p65)surrogate

BEV 2C protein promotes viral replication by inhibiting the NF-κB signaling pathway through targeting IKBKB and p65, providing novel insights into enterovirus pathobiology.

Cite This Study

Cui et al. (2025) studied this question.

synapsesocial.com/papers/6a8fdfb0b20e39831e41440e https://doi.org/10.1186/s13567-025-01453-8

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February 16, 2025Veterinary ResearchOpen Access

BEV 2C protein inhibits the NF-κB signalling pathway to promote viral replication by targeting IKBKB and p65

View Full Paper

Ask AI

Bookmark

Why the study?

The mechanisms by which bovine enteroviruses evade the host immune response and promote their replication remain unclear.

Population

HY12 strain of enterovirus model

Design

Preclinical laboratory study

Authors

XCXuyuan CuiJilin University YGYidi GuoNanjing University of Chinese Medicine FZFan ZhangWuhan College

Discussion

Member takes

Implication

BEV 2C inhibition of NF-κB may aid viral persistence in cattle; leaves open targeted antiviral development pending in vivo validation.

Structured PICO

Population

Bovine enterovirus HY12 strain model (host interaction)

Intervention

BEV 2C protein (specifically N-terminal 1-121 aa)

Outcome

Viral replication and NF-κB pathway inhibition (down-regulation of IKBKB, interaction with p65)surrogate

BEV 2C protein promotes viral replication by inhibiting the NF-κB signaling pathway through targeting IKBKB and p65, providing novel insights into enterovirus pathobiology.

Cite This Study

Cui et al. (2025) studied this question.

synapsesocial.com/papers/6a8fdfb0b20e39831e41440e https://doi.org/10.1186/s13567-025-01453-8

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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