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January 1, 1979Intervirology

Bovine Enterovirus CPE at Different Multiplicities of Infection in the Absence of Viral RNA Synthesis

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Key result

HBB enhances bovine enterovirus cytopathology, suggesting viral proteins drive damage independently of double-stranded RNA.

Population

Bovine enterovirus (BEV) infected cells

Design

Preclinical

Authors

RLRoy A. LevineCornell UniversityDWDavid WolffAugusta University

Discussion

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Implication

May implicate viral proteins in enteroviral cytopathology independent of dsRNA; hypothesis-generating in animal models and requires human validation.

Structured PICO

P
Population
Bovine enterovirus (BEV) infected cells
I
Intervention
2-(alpha-hydroxybenzyl)-benzimidazole (HBB) at different multiplicities of infection (MOI)
O
Outcome
Cytopathologysurrogate

Viral proteins may play a role in the development of cytopathology independently of viral double-stranded RNA.

Cite This Study

Levine et al. (1979) studied Bovine enterovirus infection (in vitro). 2-(alpha-hydroxybenzyl)-benzimidazole (HBB) and varying MOI was evaluated on Cytopathology. Inhibition of bovine enterovirus RNA synthesis by HBB with increasing MOI enhanced cytopathology, suggesting viral proteins drive cytopathology independently of double-stranded RNA.

synapsesocial.com/papers/6aa88a09c9bfadd95cb44007https://doi.org/10.1159/000149042
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